Large Quantitative Models

Trained on physics, chemistry, biology, and math to model the real world.
SandboxAQ is leading the next wave of enterprise AI with Large Quantitative Models (LQMs) — grounded in physics and built to simulate real-world systems. Across biopharma, chemicals, advanced materials, cybersecurity, healthcare, navigation, and more—LQMs provide the scientific accuracy and computational scale to solve the world’s most complex challenges.

SandboxAQ is collaborating with NVIDIA to accelerate breakthrough innovations across biopharma, chemicals, advanced materials, financial services, cybersecurity, navigation, and medical imaging.

SandboxAQ is now uniquely positioned to help customers tackle the most complex and consequential business challenges through its LQMs—delivering breakthroughs where traditional models have fallen short—while offering unparalleled speed, scalability, and precision.

Our latest scientific breakthrough papers in two infographics:

LQMs explained by leading voices

IQT interview with Jack Hidary

Nadia Harden, GM AI Simulation

IQT interview with Jack Hidary

Martin Ganahl, Senior Scientist

Where LQMs are Making an Impact Today

LQMs Drive Discovery and Impact
Across the World's Largest Industries

Drug Discovery

Powered by NVIDIA DGX Cloud’s advanced computing infrastructure on Google Cloud, SandboxAQ is redefining how new drugs are discovered with a new class of AI purpose-built for science. Instead of relying on slow, experimental cycles, SandboxAQ's AQBioSim uses Large Quantitative Models (LQMs) grounded in physics and chemistry to simulate molecular behavior with scientific precision.

AQBioSim enables biopharma teams to model interactions, predict outcomes, and optimize drug candidates—all in silico. Combined with the Agentic AI Chemist orchestrating simulation workflows, SandboxAQ's solutions can explore vast chemical spaces, prioritize high-potential compounds, and accelerate discovery up to 4x. With LQMs, biopharma teams can:
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Cut discovery timelines from years to weeks with simulation-first workflows.
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Improve candidate quality with subatomic-level molecular binding models.
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Predict toxicity and efficacy earlier to reduce trial failures.

Chemicals & Materials

Traditional R&D runs on iteration. SandboxAQ’s AQChemSim platform empowers teams to simulate the physical world before entering the lab. Built on first principles of physics, chemistry, and materials science, AQChemSim uses LQMs to deliver high-fidelity predictions of how molecules, materials, and industrial systems behave under real-world conditions.

SandboxAQ’s AI Chemist brings together multiple Large Quantitative Models (LQMs) to reimagine the R&D process from the ground up. It intelligently orchestrates large-scale collaboration, exploring millions of potential pathways. Trained on first principles of physics, chemistry, and materials science, these LQMs deliver unprecedented insights into how molecules, materials, and industrial systems behave under real-world conditions. This enables top R&D teams to:
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Predict performance under thermal, mechanical, and electrical stress.
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Accelerate formulation through in silico testing and validation.
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Explore and optimize sustainable chemical processes.
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Shorten development cycles from years to weeks with greater precision.

Cybersecurity

Today’s enterprises are flooded with AI agents and machine-to-machine communications—each creating cryptographic assets and Non-Human Identities (NHIs) at massive scale. Traditional security tools can’t keep up. Most organizations lack real-time visibility and control over where cryptography is used, where it's vulnerable, and how to fix it fast.

AQtive Guard is a first-of-its-kind platform that uses Large Quantitative Models (LQMs) to transform cryptographic and identity management. Designed to secure the modern enterprise, AQtive Guard gives security teams deep, AI-powered insight into cryptographic assets and NHIs—then automates remediation before threats become breaches.

Built for speed, scale, and intelligence, AQtive Guard works across your existing infrastructure and cloud environments to deliver unmatched visibility, prioritized risk analysis, and policy enforcement. With AQtive Guard, your team can:
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Discover and monitor cryptographic assets and NHIs across hybrid environments.
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Apply LQM-powered risk analysis to surface high-impact vulnerabilities with minimal noise.
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Detect and remediate weak, expired, or non-compliant keys, certs, and algorithms.
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Automate lifecycle management including credential rotation and certificate renewal.
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Accelerate compliance with FIPS 140-2, PCI DSS, NIST, and custom policies.
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Get ready for the quantum future with post-quantum cryptography support.
Quantitative AI and Quantum Technologies

Transform Major Challenges​ Into Global Breakthroughs​.